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REGULATORY TRACKER

MHRA enforcement and safety tracker

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Trustly Pharma Analytical Board · Regulatory Intelligence DeskLast updated: 06 October 2026

The MHRA published 23 items in the 90 days to 2026-10-06, of which 4 relate to weight-loss medicines or synthetic peptides, 2 concern enforcement against illegal or unlicensed supply, and 3 are formal Drug Safety Updates. This page restates what the regulator published and links to each gov.uk original. It is an independent reporting record, not advice.

23MHRA items in the window
4Relevant to this site
2Enforcement actions
3Drug Safety Updates

Full MHRA record, last 90 days

Everything the MHRA published between 2026-07-06 and 2026-10-06, newest first. We list the full record rather than only selected parts, so every item can be audited directly against the official government register.

DateTypeItemRelevant Here
2026-10-01ANNOUNCEMENTMHRA joins global regulators in call to advance alternatives to animal testing

International regulatory coalition promoting microphysiological systems and in vitro non-animal assays for pharmaceutical screening.

No
2026-09-30ANNOUNCEMENTDIA and MHRA announce speaker line-up for inaugural global summitNo
2026-09-24ENFORCEMENTMHRA welcomes sentencing after fraud convictions over falsely certified medical devices

Criminal convictions secured following joint Trading Standards and MHRA prosecution into counterfeit compliance certification.

No
2026-09-24ANNOUNCEMENTFive new commissioners appointed to the Commission on Human Medicines (CHM)No
2026-09-24ANNOUNCEMENTProfessor Dame Anna Dominiczak, Professor Alison Strath, and Fiona Cochrane: Catalysing the medicines ecosystem in ScotlandNo
2026-09-23ANNOUNCEMENTMHRA approves lurbinectedin for adults with extensive-stage small cell lung cancerNo
2026-09-22ANNOUNCEMENTFunding opportunity launched to strengthen UK regulatory science and support healthcare innovationNo
2026-09-16ANNOUNCEMENTMHRA sets out steps to prevent avoidable harm from patient hoistsNo
2026-09-15ANNOUNCEMENTMHRA and Malaysia strengthen partnership on healthcare innovation and researchNo
2026-09-10ANNOUNCEMENTIndependent Commission led by NHS doctors sets out blueprint to accelerate safe AI adoption in healthcareNo
2026-09-02DRUG SAFETY UPDATEFilters should be used during the administration of Parenteral Nutrition for patients in all care settingsNo
2026-09-02ANNOUNCEMENTMHRA and Manchester NHS partner on health innovation sandboxNo
2026-09-01ANNOUNCEMENTMHRA concludes review of Avacopan Vifor following reassessment of benefit-risk balanceNo
2026-09-01ANNOUNCEMENTMHRA regulatory reform amendments tabled in Government's Health BillNo
2026-08-27ANNOUNCEMENTCari-Anne Quinn: Turning possibility into progress - health innovation in WalesNo
2026-08-26ANNOUNCEMENTIncreased risk of wear and corrosion identified with certain cobalt chrome modular neck hip replacementsNo
2026-08-20ANNOUNCEMENTMHRA advises against using rectal catheters sold for personal use in infantsNo
2026-08-18ANNOUNCEMENTMHRA sets out position on regulation of microbiome-based medicinal productsNo
2026-08-14ANNOUNCEMENTVimseltinib (romvimza) approved for use in adults to treat tenosynovial giant cell tumoursNo
2026-08-13ANNOUNCEMENTYou've got the grades, but don't pass on your healthNo
2026-08-12ANNOUNCEMENTMHRA reaffirms the safety of childhood vaccinationNo
2026-07-03ANNOUNCEMENTMHRA grants conditional approval for semaglutide (Wegovy) to treat MASH in adults with moderate to advanced liver fibrosis

MHRA approves expanded metabolic indications for synthetic semaglutide in non-cirrhotic MASH patients with stage F2/F3 fibrosis.

Yes
2026-06-18ANNOUNCEMENTMHRA, ASA and GPhC issue a joint warning on promoting newly licensed prescription-only and unlicensed weight-management medicines

Joint national enforcement directive emphasizing strict prohibition on direct-to-consumer advertising of POM GLP-1 medicines and unapproved peptide analogues.

Yes

Detailed Case Dossiers: Peptides & GLP-1 Enforcement

In-depth analysis of high-impact regulatory interventions, laboratory raid reports, court orders, and cross-regulator warnings impacting the synthetic peptide sector.

MHRAPolicy Guidance2026-07-03
Ref: MHRA-MA-2026-703

Conditional Approval: Semaglutide (Wegovy) for Non-Cirrhotic MASH Liver Fibrosis

MHRA grants conditional marketing authorization for semaglutide to treat adult patients with non-cirrhotic metabolic dysfunction-associated steatohepatitis (MASH) and moderate-to-advanced hepatic scarring.

Compounds Cited:
Semaglutide
Statutory Provision:Human Medicines Regulations 2012, Regulation 58
MHRAAdvertising Sanction2026-06-18
Ref: MHRA-ASA-GPHC-2026-06

National Warning: Public Advertising Prohibition on Licensed & Unlicensed GLP-1 and Peptides

MHRA, ASA and GPhC jointly caution commercial entities against promoting prescription-only or unlicensed research peptides directly to consumers.

Compounds Cited:
SemaglutideTirzepatideRetatrutideBPC-157
Statutory Provision:CAP Code Rule 12.11 / Human Medicines Regulations 2012 Regulation 284
MHRAPolicy Guidance2026-06-11
Ref: MHRA-POM-2026-611

First Oral Peptide Tablet Approved for UK Weight Management (Prescription Only)

MHRA clears oral formulation of GLP-1 receptor agonist under strict POM classification, reiterating ban on general public advertising.

Compounds Cited:
Semaglutide (Oral)
Statutory Provision:Human Medicines Regulations 2012, Regulation 46
MHRAEnforcement Action2026-05-29
Ref: MHRA-ENF-2026-529

Criminal Enforcement: Interception of 12,000 Unlicensed Doses Including Retatrutide & Peptides

Special Investigations Unit carried out arrests and recovered 12,000 doses of unlicensed synthetic peptides manufactured without GMP standards.

Compounds Cited:
RetatrutideTirzepatideBPC-157
Statutory Provision:Human Medicines Regulations 2012, Regulation 17 (Manufacturing Licences)
UK Border ForceEnforcement Action2026-05-13
Ref: EWHC-CH-2026-1049

High Court ISP Block Order: Dynamic Web Filtering for Counterfeit Peptide Portals

High Court orders top UK internet providers to implement dynamic domain filtering against rogue illicit drug websites supplying unapproved peptide vials.

Compounds Cited:
SemaglutideTirzepatide
Statutory Provision:Senior Courts Act 1981, Section 37(1)
MHRASafety Alert2026-02-24
Ref: MHRA-DSU-2026-02

Drug Safety Alert: Falsified Tirzepatide Multidose Cartridges Intercepted

National alert identifying counterfeit batch lots with unverified sterility and non-standard peptide concentrations circulating in grey market supply chains.

Compounds Cited:
Tirzepatide
Statutory Provision:Human Medicines Regulations 2012, Regulation 46

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Trustly Pharma is an independent analytical publication. Nothing here replaces the statutory authority of the MHRA, GPhC, or ASA. Direct official portals for independent verification are indexed below.

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