Ipamorelin
Aib-His-D-2-Nal-D-Phe-Lys-NH2 Pentapeptide GHSR Agonist
Ipamorelin is a synthetic pentapeptide and selective ghrelin/growth hormone secretagogue receptor 1a (GHSR-1a) agonist. It demonstrates exquisite somatotroph selectivity, eliciting endogenous growth hormone pulses without significantly raising adrenocorticotropic hormone (ACTH), cortisol, prolactin, or aldosterone.
Indexed for laboratory in vitro receptor binding assays and cellular synthesis research. Commercial materials are procured as non-clinical reagents under verified laboratory standards.
Chemical Structure & Metrics
Structured Chemical & Preclinical Profile
1. Chemical Identity & Sequence Architecture
Ipamorelin (Aib-His-D-2-Nal-D-Phe-Lys-NH2 Pentapeptide GHSR Agonist) is an analytically characterized peptide with empirical formula C38H49N9O5 (MW 711.86 g/mol). CAS Registry: 170851-70-4.
2. Primary Preclinical Signaling Axis
Investigated in preclinical assays for cellular signaling: Selective agonism of pituitary and hypothalamic GHSR-1a receptors, activating phospholipase C (PLC) pathways.
3. Physical Formats & Delivery Matrices
Synthesized predominantly as high-purity lyophilized powder cakes, with secondary pre-metered pen cartridges and solution atomizers cataloged across vendors.
4. Reconstitution & Analytical Handling
Recommended reconstitution with Bacteriostatic Water USP. Lyophilized cake stored at -20°C dry. Solution stable at 2°C to 8°C refrigerated (stable 28 days).
Signaling Pathways & Laboratory Handling Protocols
Documented Receptor Pathways & In Vitro Signaling
Selective agonism of pituitary and hypothalamic GHSR-1a receptors, activating phospholipase C (PLC) pathways.
Intracellular inositol trisphosphate (IP3) generation prompting controlled calcium release and GH vesicle exocytosis.
Absolute lack of stimulatory activity at ghrelin receptors regulating appetite or gastrointestinal hypermotility in standard assays.
Synergistic amplification of GH release when co-administered with GHRH analogs like CJC-1295.
Regarded in peptide pharmacological literature as the cleanest third-generation secretagogue with zero significant binding affinity at off-target neuroendocrine receptors.
Handling Parameters
Peptide Dilution & Reconstitution Calculator
Compute stock concentrations, micro-pipetting draw volumes, and U-100 syringe units with zero procedural guesswork.
Slowly introduce bacteriostatic diluent against the internal glass vial wall. Swirl gently in a circular horizontal rotation. Never shake or vortex vigorously to prevent mechanical shearing of delicate peptide bonds. Store reconstituted stock at 2°C–8°C.
Partner & Vendor Catalogues for Ipamorelin
Independent partner directory providing research-grade lyophilized vials, cartridges, atomizers, and reconstitution solvents.
Category hub featuring research-grade lyophilized vials, pens, and blends.
Full catalogue category hub with multiple mg vial sizes and blends.
Dedicated category hub listing research vials and cartridges.
UK-stocked research reagent catalogue hub featuring batch-verified peptide lots.
Global catalogue hub including international dispatch batches.
Academic Bibliography & Preclinical Studies for Ipamorelin
Primary academic indexing sourced from PubMed and peer-reviewed biotechnology journals documenting molecular mechanisms and in vitro cellular response.
Ipamorelin, the first selective growth hormone secretagogue
Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers
Ipamorelin, a new growth-hormone secretagogue, induces longitudinal bone growth in rats
Frequently Asked Chemical & Analytical Questions
Authoritative scientific clarifications regarding Ipamorelin classification, molecular pathways, and laboratory protocols.
Ipamorelin (Aib-His-D-2-Nal-D-Phe-Lys-NH2 Pentapeptide GHSR Agonist) is an analytically characterized peptide compound with empirical molecular formula C38H49N9O5 and molecular weight 711.86 g/mol. It is indexed under CAS Registry Number 170851-70-4 and categorized in research literature under Growth Hormone Secretagogues & GHRH.