Epithalon
Ala-Glu-Asp-Gly Synthetic Pineal Tetrapeptide (AEDG / Epitalon)
Epithalon is a synthetic biomimetic tetrapeptide modeled after the endogenous pineal peptide epithalamin. Investigated for its ability to induce telomerase reverse transcriptase (TERT) expression, elongate telomeres in human somatic cells, modulate melatonin synthesis, and reduce oxidative mitochondrial stress.
Indexed for laboratory in vitro receptor binding assays and cellular synthesis research. Commercial materials are procured as non-clinical reagents under verified laboratory standards.
Chemical Structure & Metrics
Structured Chemical & Preclinical Profile
1. Chemical Identity & Sequence Architecture
Epithalon (Ala-Glu-Asp-Gly Synthetic Pineal Tetrapeptide (AEDG / Epitalon)) is an analytically characterized peptide with empirical formula C14H22N4O9 (MW 390.35 g/mol). CAS Registry: 307297-39-8.
2. Primary Preclinical Signaling Axis
Investigated in preclinical assays for cellular signaling: Upregulation of telomerase activity (TERT) resulting in elongation of telomere repeats in human cell cultures.
3. Physical Formats & Delivery Matrices
Synthesized predominantly as high-purity lyophilized powder cakes, with secondary pre-metered pen cartridges and solution atomizers cataloged across vendors.
4. Reconstitution & Analytical Handling
Recommended reconstitution with Bacteriostatic Water or Sterile Purified Water. Lyophilized cake stored at -20°C desiccated (stable up to 24 months). Solution stable at 2°C to 8°C refrigerated (stable 28 days).
Signaling Pathways & Laboratory Handling Protocols
Documented Receptor Pathways & In Vitro Signaling
Upregulation of telomerase activity (TERT) resulting in elongation of telomere repeats in human cell cultures.
Regulation of pineal gland gene expression and circadian nocturnal melatonin secretion patterns.
Antioxidant scavenging and attenuation of lipid peroxidation and reactive oxygen species (ROS) in cell models.
Modulation of chromatin accessibility and epigenetic methylation patterns across age-associated gene loci.
Investigated in biogerontological models, organotypic explants, and cell culture assays for chromosome end-cap stabilization and cellular senescence dynamics in somatic culture models.
Handling Parameters
Peptide Dilution & Reconstitution Calculator
Compute stock concentrations, micro-pipetting draw volumes, and U-100 syringe units with zero procedural guesswork.
Slowly introduce bacteriostatic diluent against the internal glass vial wall. Swirl gently in a circular horizontal rotation. Never shake or vortex vigorously to prevent mechanical shearing of delicate peptide bonds. Store reconstituted stock at 2°C–8°C.
Partner & Vendor Catalogues for Epithalon
Independent partner directory providing research-grade lyophilized vials, cartridges, atomizers, and reconstitution solvents.
Category hub featuring research-grade lyophilized vials, pens, and blends.
Full catalogue category hub with multiple mg vial sizes and blends.
Dedicated category hub listing research vials and cartridges.
UK-stocked research reagent catalogue hub featuring batch-verified peptide lots.
Global catalogue hub including international dispatch batches.
Academic Bibliography & Preclinical Studies for Epithalon
Primary academic indexing sourced from PubMed and peer-reviewed biotechnology journals documenting molecular mechanisms and in vitro cellular response.
Peptide promotes telomerase activity and telomere elongation in human fibroblasts
Geroprotective effect of epithalamin and epithalon: telomerase and longevity
Frequently Asked Chemical & Analytical Questions
Authoritative scientific clarifications regarding Epithalon classification, molecular pathways, and laboratory protocols.
Epithalon (Ala-Glu-Asp-Gly Synthetic Pineal Tetrapeptide (AEDG / Epitalon)) is an analytically characterized peptide compound with empirical molecular formula C14H22N4O9 and molecular weight 390.35 g/mol. It is indexed under CAS Registry Number 307297-39-8 and categorized in research literature under Cellular Longevity & Mitochondrial Axis.