BPC-157
Body Protection Compound 157 Pentadecapeptide
BPC-157 is a 15-amino-acid synthetic peptide derived from human gastric juice protein BPC. Preclinical laboratory models investigate its interaction with focal adhesion kinase (FAK), vascular endothelial growth factor receptor 2 (VEGFR2), and early growth response protein 1 (egr-1).
Indexed for laboratory in vitro receptor binding assays and cellular synthesis research. Commercial materials are procured as non-clinical reagents under verified laboratory standards.
Chemical Structure & Metrics
Structured Chemical & Preclinical Profile
1. Chemical Identity & Sequence Architecture
BPC-157 (Body Protection Compound 157 Pentadecapeptide) is an analytically characterized peptide with empirical formula C62H98N16O22 (MW 1419.55 g/mol). CAS Registry: 137525-51-0.
2. Primary Preclinical Signaling Axis
Investigated in preclinical assays for cellular signaling: Upregulation of VEGFR2 transcription and early angiogenic vessel collateralization in ischemic microenvironments.
3. Physical Formats & Delivery Matrices
Synthesized predominantly as high-purity lyophilized powder cakes, with secondary pre-metered pen cartridges and solution atomizers cataloged across vendors.
4. Reconstitution & Analytical Handling
Recommended reconstitution with Bacteriostatic 0.9% Benzyl Alcohol USP or Sterile Purified Water. Lyophilized cake stored at -20°C desiccated (stable up to 24 months). Solution stable at 2°C to 8°C refrigerated; protect from light (stable 28 days).
Signaling Pathways & Laboratory Handling Protocols
Documented Receptor Pathways & In Vitro Signaling
Upregulation of VEGFR2 transcription and early angiogenic vessel collateralization in ischemic microenvironments.
Activation of the FAK-Paxillin phosphorylation cascade, mediating in vitro tendon and ligament fibroblast migration.
Modulation of nitric oxide (NO) synthase isoforms (eNOS and iNOS) in capillary endothelium.
Downregulation of pro-inflammatory cytokines TNF-alpha and IL-6 in explanted tissue assays.
Extensively cataloged in preclinical animal models for microvascular integrity, soft tissue transection models, and mucosal epithelial cellular barrier integrity. It is handled exclusively for in vitro and laboratory evaluation.
Handling Parameters
Peptide Dilution & Reconstitution Calculator
Compute stock concentrations, micro-pipetting draw volumes, and U-100 syringe units with zero procedural guesswork.
Slowly introduce bacteriostatic diluent against the internal glass vial wall. Swirl gently in a circular horizontal rotation. Never shake or vortex vigorously to prevent mechanical shearing of delicate peptide bonds. Store reconstituted stock at 2°C–8°C.
Partner & Vendor Catalogues for BPC-157
Independent partner directory providing research-grade lyophilized vials, cartridges, atomizers, and reconstitution solvents.
Category hub featuring research-grade lyophilized vials, pens, and blends.
Full catalogue category hub with multiple mg vial sizes and blends.
Dedicated category hub listing research vials and cartridges.
UK-stocked research reagent catalogue hub featuring batch-verified peptide lots.
Global catalogue hub including international dispatch batches.
Academic Bibliography & Preclinical Studies for BPC-157
Primary academic indexing sourced from PubMed and peer-reviewed biotechnology journals documenting molecular mechanisms and in vitro cellular response.
Brain-gut axis and pentadecapeptide BPC 157: Theoretical and practical implications
Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts
BPC 157 and blood vessels: Modulation of angiogenesis and endothelial integrity
Frequently Asked Chemical & Analytical Questions
Authoritative scientific clarifications regarding BPC-157 classification, molecular pathways, and laboratory protocols.
BPC-157 (Body Protection Compound 157 Pentadecapeptide) is an analytically characterized peptide compound with empirical molecular formula C62H98N16O22 and molecular weight 1419.55 g/mol. It is indexed under CAS Registry Number 137525-51-0 and categorized in research literature under Tissue Repair & Angiogenesis.